The results of protocol development, which physicians implement to decrease medical risk, can be of interest to third parties. For example, a protocol that seeks to ensure patients with heart failure are using recommended doses of ACE inhibitors would be of interest to the manufacturers of ACE inhibitors.

For these types of protocols, CSS has found interested sponsors. Physicians willing to share protocol results (in the aggregate - no specific patient or physician information is shared), can often obtain funding for protocol implementation.